The role of KP-10 in osteoblast differentiation has not yet been elucidated.
In this study, we demonstrate that KP-10 regulates BMP2 expression and activation through the GPR54/NFATc4 signaling cascade, and subsequently increases expression of early stage osteogenic marker genes such as Dlx5 and Runx2 via BMP2-induced Smad1/5/9 phosphorylation.
Kristaps Porzingis' torn ACL is healing just fine, thanks to some expert medical attention from a smoke show blonde in a lab coat -- and by lab coat, we mean bikini. Not to mention, he's even feeling good enough for a leap into the ocean! KP has been rehabbing his knee in Spain with Real Madrid's actual medical staff. There's buzz about a possible trade of Porzingis to the Spurs for Kawhi Leonard -- which means Greg Popovich is gonna LOVE these pics.
KP-10 significantly induced expression of osteogenic marker genes in a dose-dependent manner (Fig. In addition, 50 μM of KP-10 significantly increased expression of osteogenic marker genes in a time-dependent manner (Fig. Real-time PCR analysis showed that KP-10 also significantly increased expression of osteogenic marker genes (Fig. Accumulated circumstantial evidence indicates that ALP plays an important role in the formation and calcification of hard tissues.
Porzingy's ACL injury could reportedly keep him off the court for the first 2 months of next season -- but maybe these pics are a sign he could be back sooner.
Kisspeptin-10 (KP-10) acts as a tumor metastasis suppressor via its receptor, G-protein-coupled receptor 54 (GPR54).
In addition, NFATc1 is reported to have crucial roles in the proliferation of osteoblasts.
NFATs also function in osteoblasts to regulate factors that are crucial for the recruitment of osteoclast precursors to bone.